Biblioteca virtual en Vacunas  
Biblioteca virtual en Vacunas
Biblioteca Virtual en Vacunas
Red Latinoamericana de Información Científico Técnico en Vacunas
 
 
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Martes, 17/9/2019

VacciMonitor
Biotecnología Aplicada


Resumen
Lactoferrin is the major antimicrobial agent present in human milk, where it has a significant role in the protective effects ascribed to breast-feeding. The mechanisms of the antimicrobial effects of lactoferrin are critically discussed in relation to important bacterial and viral pathogens and the most promising areas for basic and applied research are specifically highlighted. Applications of lactoferrin in the study of the mechanisms of iron uptake by microbial pathogens, as well as in the diagnosis of gastrointestinal inflammation of infectious and autoimmune origin, are addressed. The progress in the use of lactoferrin as an immunomodulating agent are briefly discussed and the observed side effects of lactoferrin administration are singled out for consideration in clinical studies. As with the rest of the components of the innate immune system, the final outcome of the biological activity of lactoferrin is the result of combined effects with other innate and adaptive immune factors. In this regard, the availability of recom-binant lactoferrin will allow clinical trials addressing the innocuity and efficacy of single or combined formulations of lactoferrin with other biologically active molecules. Diseases such as AIDS, chronic Hepatitis C, bacterial sepsis, arthritis, and bacterial infections in diabetic subjects, which lack effective treatment and have the potential to be modulated by lactoferrin, may be considered as targets for such trials. Lactoferrin research has reached a stage where a rigurous clinical evaluation of the multiple effects observed in vitro would provide a definitive answer to its actual antimicrobial and diagnostic value. Biotecnología Aplicada 2001;18:76-83
 

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